Diphenoxylate (Lomotil, R-1132) is a centrally active opioid drug of the phenylpiperidine series that is used as a combination drug, prescribed in the
Diphenoxylate/atropine, also known as co-phenotrope and sold under the brand name Lomotil among others, is used to treat diarrhea. It is a fixed-dose
treatment of a number of types of diarrhea. Loperamide is often compared to diphenoxylate. Studies suggest that loperamide is more effective and has lower neural
bulk-forming agents. Commonly used medications include loperamide (Imodium), diphenoxylate, bismuth subsalicylate (Pepto-Bismol), Cholestyramine, and Octreotide
bemidones (e.g., ketobemidone), and others more distant, including diphenoxylate and analogues. Pethidine is indicated for the treatment of moderate
as pethidine (meperidine), ketobemidone, alvimopan, loperamide, and diphenoxylate. MPTP Phenylpiperidine Media related to 4-Phenylpiperidine at Wikimedia
derivatives. Certain other opioids, including alvimopan, loperamide, and diphenoxylate, are 4-phenylpiperidine derivatives as well. 2-Phenylpiperidine 3-Phenylpiperidine
or malabsorption), but it does decrease motility. Examples include diphenoxylate, loperamide, and eluxadoline. Boxtel, C. J. van; Santoso, Budiono; Edwards
containing the equivalent of more than 90 mg of codeine per dosage unit; Diphenoxylate (pure) Fentanyl and most other strong pure opioid agonists, e.g. levorphanol
Giardia, helminths, or cholera. Antimotility drugs such as loperamide and diphenoxylate reduce the symptoms of diarrhea by slowing transit time in the gut.